Pg. 97 "'Information Theory of Aging' According to David Sinclair, most chronic or degenerative diseases--the ones that hijack our energy and degrade our health--aren't hardwired into our genes. In reality, they're the result of bad 'information' that makes our genes turn 'on' or 'off' at the wrong times or in the wrong places in the body. It's like corrupted code on a computer hard drive, only on a molecular level."
Pg. 98 "Aging, quite simply, is a loss of information. That's another way of saying that aging is entropy, the disorder that results from missing or corrupted data.
David Sinclair's Three Principles of Aging
Principle #1: Aging is a disease, which means it's not inevitable--or acceptable.
Principle #2: Aging is a single malady with many manifestations from heart disease to cancer to diabetes to autoimmune disorders.
Principle #3: Aging is treatable and even reversible.
Pg. 99 "Sinclair's chronological age is 53, but his biological age is around two decades younger. For the record, it's our biological age that matters. How does he do it? First of all, he's smart about what he eats; he's especially careful to limit his red meat and avoids almost all sugar. Second, he confines himself to one meal per day (dinner). Third, he moderates his intake of alcohol. Fourth, he strives to get eight hours of sleep per night. Fifth, he exercises at least three days per week."
Pg. 101 "He takes a vitamin cocktail, D3 and K2. D3 has been scientifically proven to strengthen our bones, balance our hormones, and fortify our immune systems. Meanwhile, vitamin K2 actually keeps your arteries from clogging with calcium plaques, a leading cause of heart attacks.
Pg. 102 "He takes a gram of metformin, the pennies-per-does first-line treatment for type 2 diabetes that could have a far-reaching impact--even if you're not diabetic. By boosting our sensitivity to insulin and thereby lowering our blood glucose.
Pg. 105 "For some time I've understood that our quality of life is determined by our emotions. If you've got a billion dollars and you're angry all the time, your life is anger. If you've got beautiful children and you're worried all the time, your life is worry. But emotions don't exist in isolation. They're heavily influenced by your physiology, most of all by your energy. Low energy tends to bring negative emotions."
Pg. 106 Mitochondria create the fuel that powers each and every cell in our bodies. They live in the cytoplasm, the salty sea between a cell's outer membrane and its nucleus. Their biggest job is to import nutrients, break them down, and turn them into complex molecules called ATP, the cells' battery packs."
Pg. 107 "By 2050, the segment of the world's population over 60 will be nearly twice what it is today--more than 2 billion people, nearly one of five souls on Earth."
"The typical person in the United States now lives to 79. Once we make it to 65, statistics show that we can look forward to another 19 years, on average. A healthy 80-year-old free of terminal illness, has a good shot at lasting another decade or more, to 90 years-plus.
Pg. 108 "Overall, more than two of three deaths come from one or more of the Big Six: heart disease, cancer, stroke, chronic obstructive pulmonary disease, diabetes, and Alzheimer's. Here's a question: What's the biggest risk factor for these devastating conditions? Smoking? Too many nightcaps? Big Gulps with a double helping of McDonald's fries? The answer is none of these. The biggest risk factor by far is aging. While smoking increases your cancer risk fivefold, according to Sinclair, aging raises it five-hundred-fold. Aging itself is the mother of virtually all diseases--including infectious diseases."
Pg. 109 "A 20-year-old heart can pump ten times as much blood as the body needs. But around the time we hit 30, we're losing some of that reserve each year. Our hormone and stem cell levels also drop off a cliff between the ages of 30 and 40. Why? Because we weren't designed by evolution to live past 35."
Pg. 111 "Every cell in your body has an identical instruction set of 3.2 billion letters from your mother and 3.2 billion letters from your father. These letters make up your DNA and are known as your genome. Your genome codes for some 30,000 proteins that are the enzymes and building blocks of life. The proteins your genome codes for at birth are the very same they code for when you are 80 years old!"
Pg. 112 "When it comes to our healthsplan, lifespan, and how our body and mind function each day, our genes and DNA are not our destiny. The epigenome, which controls gene expression, is the main mechanism that decides our destiny."
"Sirtuins are a set of seven regulatory genes that have two different and competing functions in your cells. First, they govern the epigenome, turning the right genes on at the right time and in the right cell, boosting mitochondrial activity, reducing inflammation, and protecting telomeres. And second, they have another critical function in directing DNA repair."
Pg. 113 "We now know that our sirtuins can't do much of anything--including fixing our DNA--without a heaping helping of NAD+, a molecule that is critical to power the entire sirtuins system. So it's sobering to learn that we lose about half our NAD+ by our 50s, right about the time when we need it more than ever to function at peak efficiency."
Pg. 114 "It's now generally accepted that the shrinkage and death of our microcapillaries, our smallest blood vessels, is a primary aspect of aging."
Pg. 116 "In 2006, a Japanese researcher named Shinya Yamanaka made a thunderclap, Nobel Prize-winning discovery that changed the course of medicine and human biology. He showed that a set of four genes could transform garden-variety adult stem cells into age-zero stem cells. These manipulated stem cells--known by scientists as induced pluripotent stem cells--had the magical ability to repair or replace injured tissue anywhere in the body. By pushing cells back in time, decades of epigenetic scuffs could be wiped away."
Pg. 98 "Aging, quite simply, is a loss of information. That's another way of saying that aging is entropy, the disorder that results from missing or corrupted data.
David Sinclair's Three Principles of Aging
Principle #1: Aging is a disease, which means it's not inevitable--or acceptable.
Principle #2: Aging is a single malady with many manifestations from heart disease to cancer to diabetes to autoimmune disorders.
Principle #3: Aging is treatable and even reversible.
Pg. 99 "Sinclair's chronological age is 53, but his biological age is around two decades younger. For the record, it's our biological age that matters. How does he do it? First of all, he's smart about what he eats; he's especially careful to limit his red meat and avoids almost all sugar. Second, he confines himself to one meal per day (dinner). Third, he moderates his intake of alcohol. Fourth, he strives to get eight hours of sleep per night. Fifth, he exercises at least three days per week."
Pg. 101 "He takes a vitamin cocktail, D3 and K2. D3 has been scientifically proven to strengthen our bones, balance our hormones, and fortify our immune systems. Meanwhile, vitamin K2 actually keeps your arteries from clogging with calcium plaques, a leading cause of heart attacks.
Pg. 102 "He takes a gram of metformin, the pennies-per-does first-line treatment for type 2 diabetes that could have a far-reaching impact--even if you're not diabetic. By boosting our sensitivity to insulin and thereby lowering our blood glucose.
Pg. 105 "For some time I've understood that our quality of life is determined by our emotions. If you've got a billion dollars and you're angry all the time, your life is anger. If you've got beautiful children and you're worried all the time, your life is worry. But emotions don't exist in isolation. They're heavily influenced by your physiology, most of all by your energy. Low energy tends to bring negative emotions."
Pg. 106 Mitochondria create the fuel that powers each and every cell in our bodies. They live in the cytoplasm, the salty sea between a cell's outer membrane and its nucleus. Their biggest job is to import nutrients, break them down, and turn them into complex molecules called ATP, the cells' battery packs."
Pg. 107 "By 2050, the segment of the world's population over 60 will be nearly twice what it is today--more than 2 billion people, nearly one of five souls on Earth."
"The typical person in the United States now lives to 79. Once we make it to 65, statistics show that we can look forward to another 19 years, on average. A healthy 80-year-old free of terminal illness, has a good shot at lasting another decade or more, to 90 years-plus.
Pg. 108 "Overall, more than two of three deaths come from one or more of the Big Six: heart disease, cancer, stroke, chronic obstructive pulmonary disease, diabetes, and Alzheimer's. Here's a question: What's the biggest risk factor for these devastating conditions? Smoking? Too many nightcaps? Big Gulps with a double helping of McDonald's fries? The answer is none of these. The biggest risk factor by far is aging. While smoking increases your cancer risk fivefold, according to Sinclair, aging raises it five-hundred-fold. Aging itself is the mother of virtually all diseases--including infectious diseases."
Pg. 109 "A 20-year-old heart can pump ten times as much blood as the body needs. But around the time we hit 30, we're losing some of that reserve each year. Our hormone and stem cell levels also drop off a cliff between the ages of 30 and 40. Why? Because we weren't designed by evolution to live past 35."
Pg. 111 "Every cell in your body has an identical instruction set of 3.2 billion letters from your mother and 3.2 billion letters from your father. These letters make up your DNA and are known as your genome. Your genome codes for some 30,000 proteins that are the enzymes and building blocks of life. The proteins your genome codes for at birth are the very same they code for when you are 80 years old!"
Pg. 112 "When it comes to our healthsplan, lifespan, and how our body and mind function each day, our genes and DNA are not our destiny. The epigenome, which controls gene expression, is the main mechanism that decides our destiny."
"Sirtuins are a set of seven regulatory genes that have two different and competing functions in your cells. First, they govern the epigenome, turning the right genes on at the right time and in the right cell, boosting mitochondrial activity, reducing inflammation, and protecting telomeres. And second, they have another critical function in directing DNA repair."
Pg. 113 "We now know that our sirtuins can't do much of anything--including fixing our DNA--without a heaping helping of NAD+, a molecule that is critical to power the entire sirtuins system. So it's sobering to learn that we lose about half our NAD+ by our 50s, right about the time when we need it more than ever to function at peak efficiency."
Pg. 114 "It's now generally accepted that the shrinkage and death of our microcapillaries, our smallest blood vessels, is a primary aspect of aging."
Pg. 116 "In 2006, a Japanese researcher named Shinya Yamanaka made a thunderclap, Nobel Prize-winning discovery that changed the course of medicine and human biology. He showed that a set of four genes could transform garden-variety adult stem cells into age-zero stem cells. These manipulated stem cells--known by scientists as induced pluripotent stem cells--had the magical ability to repair or replace injured tissue anywhere in the body. By pushing cells back in time, decades of epigenetic scuffs could be wiped away."